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Target
Tyrosine-protein kinase Blk
Ligand
BDBM400813
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
30.0±n/a nM
Citation
 Gray, N; Balk, S; Liu, Q; Chen, S Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof US Patent  US10000483 Publication Date 6/19/2018 
Target
Name:
Tyrosine-protein kinase Blk
Synonyms:
B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk
Type:
Protein
Mol. Mass.:
57711.88
Organism:
Homo sapiens (Human)
Description:
P51451
Residue:
505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
  
Inhibitor
Name:
BDBM400813
Synonyms:
QL-X-138 | US10000483, Compound II-6
Type:
Small organic molecule
Emp. Form.:
C25H19N5O2
Mol. Mass.:
421.4507
SMILES:
Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1
Structure:
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