Reaction Details Report a problem with these data
Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM400826
Substrate
n/a
Meas. Tech.
Biochemical Enzymatic Assay
IC50
>10000000±n/a nM
Citation
Sprengeler, PA; Reich, SH; Webber, SE; Ernst, JT Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers US Patent US10000487 Publication Date 6/19/2018
More Info.:
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
Inhibitor
Name:
BDBM400826
Synonyms:
6'-((1,2,3-thiadiazol-5-yl)amino)-8'-chloro-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione (Cpd. No. 3) | US10000487, Example 3
Type:
Small organic molecule
Emp. Form.:
C14H14ClN5O2S
Mol. Mass.:
351.811
SMILES:
Clc1cc(Nc2cnns2)c(=O)n2c1C(=O)NC21CCCCC1