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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM400918
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Li, Y; Burns, DM; Feng, H; Huang, T; Mei, S; Pan, J; Ye, H; Zhu, W; Rafalski, M; Wang, A; Xue, C Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors US Patent  US10000507 Publication Date 6/19/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM400918
Synonyms:
2-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-4,5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide | US10000507, Example 85
Type:
Small organic molecule
Emp. Form.:
C23H30N6O3
Mol. Mass.:
438.5227
SMILES:
CCCc1cnc2c(C(=O)Nc3cnccc3N3C[C@H](C)[C@@](C)(O)[C@H](N)C3)c(N)oc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: