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Target
AMSH-like protease
Ligand
BDBM401033
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
170±n/a nM
Citation
 Deshaies, RJ; Li, J; Cohen, S; Perez, C; Ma, Y Inhibitors of RPN11 US Patent  US10005735 Publication Date 6/26/2018 
Target
Name:
AMSH-like protease
Synonyms:
AMSH-LP | AMSHLP | KIAA1373 | STALP_HUMAN | STAM-binding protein-like 1 (AMSH) | STAMBPL1
Type:
Protein
Mol. Mass.:
49789.14
Organism:
Homo sapiens (Human)
Description:
Q96FJ0
Residue:
436
Sequence:
MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSICKHVLVKDIKIIVLDLR
  
Inhibitor
Name:
BDBM401033
Synonyms:
US10005735, Compound 31
Type:
Small organic molecule
Emp. Form.:
C23H29N5O3S2
Mol. Mass.:
487.638
SMILES:
Sc1cccc2cc(cnc12)C(=O)NCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 |r|
Structure:
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