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Target
Methionine aminopeptidase 2
Ligand
BDBM401262
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
410±n/a nM
Citation
 Heinrich, T; Zenke, F; Rohdich, F; Friese-Hamim, M; Hahn, D Pyrrolidinone derivatives as MetAP-2 inhibitors US Patent  US10005756 Publication Date 6/26/2018 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM401262
Synonyms:
US10005756, Compound A25
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2FN4O3
Mol. Mass.:
513.348
SMILES:
OC1(CCN(C1=O)c1ccc2[nH]c(nc2c1)-c1ccc(Cl)cc1)C(=O)NCc1cc(F)cc(Cl)c1
Structure:
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