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Target
Methionine aminopeptidase 2
Ligand
BDBM401305
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
150±n/a nM
Citation
 Heinrich, T; Zenke, F; Rohdich, F; Friese-Hamim, M; Hahn, D Pyrrolidinone derivatives as MetAP-2 inhibitors US Patent  US10005756 Publication Date 6/26/2018 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM401305
Synonyms:
US10005756, Compound A76
Type:
Small organic molecule
Emp. Form.:
C27H24F2N4O4
Mol. Mass.:
506.5007
SMILES:
COc1ccc(Cn2ccc3cc(cnc23)N2CC[C@](O)(C(=O)NCc3cc(F)cc(F)c3)C2=O)cc1 |r|
Structure:
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