Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM401306
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
790±n/a nM
Citation
 Heinrich, T; Zenke, F; Rohdich, F; Friese-Hamim, M; Hahn, D Pyrrolidinone derivatives as MetAP-2 inhibitors US Patent  US10005756 Publication Date 6/26/2018 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM401306
Synonyms:
US10005756, Compound A77
Type:
Small organic molecule
Emp. Form.:
C12H12F2N2O3
Mol. Mass.:
270.2321
SMILES:
O[C@]1(CCNC1=O)C(=O)NCc1cc(F)cc(F)c1 |r|
Structure:
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