Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-Dependent Kinase 2 (CDK2)
LigandBDBM35181
Substrate/CompetitorHistone type 3
Meas. Tech.PKC Enzyme Assay
Temperature298.15±n/a K
IC50 10000±n/a nM
Commentsextracted
Citation Trujillo, JIKiefer, JRHuang, WThorarensen, AXing, LCaspers, NLDay, JEMathis, KJKretzmer, KKReitz, BAWeinberg, RAStegeman, RAWrightstone, AChristine, LCompton, RLi, X 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett19:908-11 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cyclin-Dependent Kinase 2 (CDK2)
Name:Cyclin-Dependent Kinase 2 (CDK2)
Synonyms:CDK2/Cyclin A2
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:CDK2/Bovine cyclin A
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Cyclin A2
Synonyms:Cyclin-A
Type:Subunit of Enzyme Complex
Mol. Mass.:29394.24
Organism:Homo sapiens (Human)
Description:n/a
Residue:256
Sequence:
DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAV
NYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEH
LVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIA
GAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNS
KYHGVSLLNPPETLNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM35181
NameBDBM35181
Synonyms:indazole-benzimidazole, 17
TypeSmall organic molecule
Emp. Form.C26H27N7O
Mol. Mass.453.5389
SMILESCOc1cc(N)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Histone type 3
Name:Histone type 3
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:It is an isolated lysine rich fraction.
Residue:3
Sequence:
n/a