Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM35276
Substrate
BDBM35258
Meas. Tech.
Neutrophil Elastase (HNE) Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
6.6±n/a nM
Citation
 Inoue, Y; Omodani, T; Shiratake, R; Okazaki, H; Kuromiya, A; Kubo, T; Sato, F Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem 17:7477-86 (2009) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM35276
Synonyms:
tripeptide-based inhibitor, 14s
Type:
Small organic molecule
Emp. Form.:
C25H37N5O10
Mol. Mass.:
567.5888
SMILES:
COC(=O)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CN1CCN(CC(O)=O)C(=O)C1=O)C(C)C)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM35258
Synonyms:
Suc-Ala-Pro-Ala-MCA
Type:
fluorogenic substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: