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Target
Dual specificity protein phosphatase 1
Ligand
BDBM34592
Substrate
OMFP Substrate
Meas. Tech.
In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM34592
Synonyms:
5,6-bis(azanyl)-3-tert-butyl-8-[2-(hydroxymethyl)piperidin-1-yl]-2-oxidanylidene-1H-pyrrolo[2,3-c][2,7]naphthyridine-9-carbonitrile | 5,6-diamino-3-tert-butyl-2-keto-8-(2-methylolpiperidino)-1H-pyrrolo[2,3-c][2,7]naphthyridine-9-carbonitrile | 5,6-diamino-3-tert-butyl-8-[2-(hydroxymethyl)-1-piperidinyl]-2-oxo-1H-pyrrolo[2,3-c][2,7]naphthyridine-9-carbonitrile | 5,6-diamino-3-tert-butyl-8-[2-(hydroxymethyl)piperidin-1-yl]-2-oxo-1H-pyrrolo[2,3-c][2,7]naphthyridine-9-carbonitrile | MLS000097492 | SMR000067074 | cid_2998196
Type:
Small organic molecule
Emp. Form.:
C21H27N7O2
Mol. Mass.:
409.4848
SMILES:
CC(C)(C)N1C(=O)Cc2c1nc(N)c1c(N)nc(N3CCCCC3CO)c(C#N)c21
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OMFP Substrate
Synonyms:
3-O-methylfluorescein phosphate | OMFP
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA