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Target
Dual specificity protein phosphatase 1
Ligand
BDBM35424
Substrate
OMFP Substrate
Meas. Tech.
In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM35424
Synonyms:
2-(4-methylanilino)-6-[(1-phenyltetrazol-5-yl)sulfanylmethyl]-1H-pyrimidin-4-one | 2-(4-methylanilino)-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1H-pyrimidin-4-one | 2-[(4-methylphenyl)amino]-6-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-1H-pyrimidin-4-one | 2-[(4-methylphenyl)amino]-6-{[(1-phenyl-1H-tetrazol-5-yl)thio]methyl}-4(3H)-pyrimidinone | 6-[[(1-phenyltetrazol-5-yl)thio]methyl]-2-(p-toluidino)-1H-pyrimidin-4-one | MLS000049564 | SMR000076092 | cid_1214377
Type:
Small organic molecule
Emp. Form.:
C19H17N7OS
Mol. Mass.:
391.45
SMILES:
Cc1ccc(Nc2nc(CSc3nnnn3-c3ccccc3)cc(=O)[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OMFP Substrate
Synonyms:
3-O-methylfluorescein phosphate | OMFP
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA