Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35491
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
9562.61±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35491
Synonyms:
Benzoic acid 5-amino-1-(4-methoxy-benzenesulfonyl)-1H-pyrazol-3-yl ester | MLS000033898 | SMR000014915 | [5-amino-1-(4-methoxyphenyl)sulfonylpyrazol-3-yl] benzoate | [5-azanyl-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] benzoate | benzoic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester | benzoic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ester | cid_655490
Type:
Small organic molecule
Emp. Form.:
C17H15N3O5S
Mol. Mass.:
373.383
SMILES:
COc1ccc(cc1)S(=O)(=O)n1nc(OC(=O)c2ccccc2)cc1N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA