Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35508
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35508
Synonyms:
MLS000089518 | N-(3-chlorophenyl)-N-ethyl-2-(1-methyl-2-oxidanylidene-quinolin-4-yl)oxy-ethanamide | N-(3-chlorophenyl)-N-ethyl-2-(1-methyl-2-oxoquinolin-4-yl)oxyacetamide | N-(3-chlorophenyl)-N-ethyl-2-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]acetamide | N-(3-chlorophenyl)-N-ethyl-2-[(1-methyl-2-oxo-4-quinolinyl)oxy]acetamide | N-(3-chlorophenyl)-N-ethyl-2-[(2-keto-1-methyl-4-quinolyl)oxy]acetamide | SMR000027866 | cid_3239997
Type:
Small organic molecule
Emp. Form.:
C20H19ClN2O3
Mol. Mass.:
370.829
SMILES:
CCN(C(=O)COc1cc(=O)n(C)c2ccccc12)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA