Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM402066
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
12.8±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G Ethyldiamine orexin receptor antagonists US Patent  US10011595 Publication Date 7/3/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM402066
Synonyms:
N-{2-[(4,6-dimethylpyrimidin-2- yl)(methyl)amino]ethyl}-N-ethyl-2- (1H-pyrazol-1-yl)pyridine-3- carboxamide | US10011595, B-24
Type:
Small organic molecule
Emp. Form.:
C20H25N7O
Mol. Mass.:
379.4588
SMILES:
CCN(CCN(C)c1nc(C)cc(C)n1)C(=O)c1cccnc1-n1cccn1
Structure:
Search PDB for entries with ligand similarity: