Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM402084
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
18.4±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G Ethyldiamine orexin receptor antagonists US Patent  US10011595 Publication Date 7/3/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM402084
Synonyms:
N-(2-{[4-chloro-6- (dimethylamino)pyrimidin- 2-yl](methyl)amino}ethyl)- N-ethyl-2-(2H-1,2,3-triazol- 2-yl)benzamide | US10011595, E-11
Type:
Small organic molecule
Emp. Form.:
C20H25ClN8O
Mol. Mass.:
428.919
SMILES:
CCN(CCN(C)c1nc(Cl)cc(n1)N(C)C)C(=O)c1ccccc1-n1nccn1
Structure:
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