Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM35836
Substrate
BDBM10852
Meas. Tech.
Radioligand Binding Assay
Ki
798±n/a nM
Citation
 Gillespie, RJ; Bamford, SJ; Clay, A; Gaur, S; Haymes, T; Jackson, PS; Jordan, AM; Klenke, B; Leonardi, S; Liu, J; Mansell, HL; Ng, S; Saadi, M; Simmonite, H; Stratton, GC; Todd, RS; Williamson, DS; Yule, IA Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides. Bioorg Med Chem 17:6590-605 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM35836
Synonyms:
pyrimidine-4-carboxamide, 118
Type:
Small organic molecule
Emp. Form.:
C14H14N6O2
Mol. Mass.:
298.3
SMILES:
Cc1ccc(o1)-c1cc(nc(N)n1)C(=O)NCc1ncc[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate