Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 2
Ligand
BDBM402291
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
17.2±n/a nM
Citation
 Zhong, H; Liao, J; Yu, H; Xu, Y; Li, Q; Chen, J; Gao, P; Tan, S; Wang, S C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof US Patent  US10011627 Publication Date 7/3/2018 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Homo sapiens (Human)
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM402291
Synonyms:
US10011627, 7
Type:
Small organic molecule
Emp. Form.:
C25H30O8
Mol. Mass.:
458.5009
SMILES:
CCCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O |TLB:30:29:22.21:26,THB:32:31:22.21:26,28:27:22.21:26|
Structure:
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