Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 2 [1-119]
Ligand
BDBM402358
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
242±n/a nM
Citation
 Zhao, Y; Wang, H; Li, G; Jiang, Y; Li, X; Zhou, L; Liu, Y Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof US Patent  US10329282 Publication Date 6/25/2019 
Target
Name:
Rho-associated protein kinase 2 [1-119]
Synonyms:
KIAA0619 | ROCK2 | ROCK2 (aa 1-119) | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13160.63
Organism:
Homo sapiens (Human)
Description:
O75116[1-119]
Residue:
119
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA
  
Inhibitor
Name:
BDBM402358
Synonyms:
US10329282, Compound TDI01292 | US11390609, Compound TDI01292
Type:
Small organic molecule
Emp. Form.:
C23H23N7O
Mol. Mass.:
413.475
SMILES:
CC(C)NC(=O)C1Cc2ccc(cc2N1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Structure:
Search PDB for entries with ligand similarity: