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Target
Rho-associated protein kinase 2 [1-119]
Ligand
BDBM399189
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
356±n/a nM
Citation
 Zhao, Y; Wang, H; Li, G; Jiang, Y; Li, X; Zhou, L; Liu, Y Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof US Patent  US10329282 Publication Date 6/25/2019 
Target
Name:
Rho-associated protein kinase 2 [1-119]
Synonyms:
KIAA0619 | ROCK2 | ROCK2 (aa 1-119) | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13160.63
Organism:
Homo sapiens (Human)
Description:
O75116[1-119]
Residue:
119
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA
  
Inhibitor
Name:
BDBM399189
Synonyms:
US10323023, Compound TDI01347 | US11390609, Compound TDI01347
Type:
Small organic molecule
Emp. Form.:
C25H19N9O
Mol. Mass.:
461.4781
SMILES:
CN(C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)c1ccnnc1
Structure:
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