Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402599
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
6.00±n/a nM
Citation
 Lim, JAltman, MDBrubaker, JDGibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent  US10329295 Publication Date 6/25/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM402599
Synonyms:
2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-bromothiophen-3- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate | US10329295, Example 14
Type:
Small organic molecule
Emp. Form.:
C17H19BrN6OS
Mol. Mass.:
435.341
SMILES:
N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3Br)n2n1 |r|
Structure:
Search PDB for entries with ligand similarity: