Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402777
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
7813±n/a nM
Citation
Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent US10329295 Publication Date 6/25/2019
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM402777
Synonyms:
N-(2-bromophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct-2- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate | US10329295, Example 84
Type:
Small organic molecule
Emp. Form.:
C19H19BrN6O
Mol. Mass.:
427.298
SMILES:
Brc1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2 |r|