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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402779
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
2271±n/a nM
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent  US10329295 Publication Date 6/25/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM402779
Synonyms:
2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct-2- yl]-N-[2- (trifluoromethyl)thiophen- 3-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate | US10329295, Example 86
Type:
Small organic molecule
Emp. Form.:
C18H17F3N6OS
Mol. Mass.:
422.427
SMILES:
FC(F)(F)c1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2 |r|
Structure:
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