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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402845
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
1035±n/a nM
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent  US10329295 Publication Date 6/25/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM402845
Synonyms:
2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}- N-(2-cyanothiophen-3- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide formate | US10329295, Example 158
Type:
Small organic molecule
Emp. Form.:
C18H17F2N7OS
Mol. Mass.:
417.436
SMILES:
N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1 |r|
Structure:
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