Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402984
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol A
IC50
0.600±n/a nM
Citation
 Trzupek, JDLee, KLBunnage, MEHan, SHepworth, DLovering, FEMathias, JPPapaioannou, NPierce, BSStrohbach, JWWright, SWZapf, CWGavrin, LKLee, AAnderson, DRCurran, KJDehnhardt, CMSaiah, EGoldberg, JAWang, XHuang, HVargas, RLowe, MDPatny, A Bicyclic-fused heteroaryl or aryl compounds US Patent  US10329302 Publication Date 6/25/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM402984
Synonyms:
US10329302, Example 131 | US10793579, Example 131 | US11702424, Example 131
Type:
Small organic molecule
Emp. Form.:
C20H24FN3O4
Mol. Mass.:
389.4207
SMILES:
CC[C@]1(F)C[C@@H](COc2nccc3cc(C(N)=O)c(OC(C)C)cc23)NC1=O |r|
Structure:
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