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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM403184
Substrate
n/a
Meas. Tech.
MTT assay
EC50
<20.0±n/a nM
Citation
 Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent  US10329303 Publication Date 6/25/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM403184
Synonyms:
US10329303, Example 20
Type:
Small organic molecule
Emp. Form.:
C26H29FN4O3S
Mol. Mass.:
496.597
SMILES:
CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3cccc(CO)c3F)c2c(=O)n(C2CC2)c1=O |(-3.39,-5.55,;-3.39,-4.01,;-4.73,-3.24,;-2.06,-3.24,;-2.06,-1.7,;-.72,-.93,;.74,-1.41,;1.65,-.16,;3.19,-.16,;3.96,-1.49,;3.48,-2.96,;2.15,-3.73,;4.73,-3.86,;5.97,-2.96,;5.5,-1.49,;6.27,-.16,;.74,1.09,;1.14,2.57,;.05,3.66,;.45,5.15,;1.94,5.55,;3.02,4.46,;4.51,4.86,;5.6,3.77,;2.63,2.97,;3.72,1.88,;-.72,.61,;-2.06,1.38,;-2.06,2.92,;-3.39,.61,;-4.73,1.38,;-6.27,1.38,;-5.5,2.71,;-3.39,-.93,;-4.73,-1.7,)|
Structure:
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