Reaction Details Report a problem with these data
Target
PRKC apoptosis WT1 regulator protein
Ligand
BDBM403268
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
IC50
1300±n/a nM
Citation
 Martel, A; Tremblay, F Heterocyclic compounds as inhibitors of platelet aggregation US Patent  US10329307 Publication Date 6/25/2019 
Target
Name:
PRKC apoptosis WT1 regulator protein
Synonyms:
PAR4 | PAWR | PAWR_HUMAN | Par-4 | Prostate apoptosis response 4 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36562.04
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
340
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
  
Inhibitor
Name:
BDBM403268
Synonyms:
US10329307, Example 15
Type:
Small organic molecule
Emp. Form.:
C25H23ClN4O4S
Mol. Mass.:
510.993
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(Cl)cc3)cc(OC)cc2o1 |r|
Structure:
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