Reaction Details Report a problem with these data
Target
PRKC apoptosis WT1 regulator protein
Ligand
BDBM403298
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
IC50
370±n/a nM
Citation
 Martel, A; Tremblay, F Heterocyclic compounds as inhibitors of platelet aggregation US Patent  US10329307 Publication Date 6/25/2019 
Target
Name:
PRKC apoptosis WT1 regulator protein
Synonyms:
PAR4 | PAWR | PAWR_HUMAN | Par-4 | Prostate apoptosis response 4 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36562.04
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
340
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
  
Inhibitor
Name:
BDBM403298
Synonyms:
US10329307, Example 45
Type:
Small organic molecule
Emp. Form.:
C29H30N4O6S
Mol. Mass.:
562.637
SMILES:
CCOC(=O)c1ccc(cc1)N1CCCCC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Structure:
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