Reaction Details Report a problem with these data
Target
PRKC apoptosis WT1 regulator protein
Ligand
BDBM403301
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
IC50
1100±n/a nM
Citation
 Martel, A; Tremblay, F Heterocyclic compounds as inhibitors of platelet aggregation US Patent  US10329307 Publication Date 6/25/2019 
Target
Name:
PRKC apoptosis WT1 regulator protein
Synonyms:
PAR4 | PAWR | PAWR_HUMAN | Par-4 | Prostate apoptosis response 4 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36562.04
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
340
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
  
Inhibitor
Name:
BDBM403301
Synonyms:
US10329307, Example 48
Type:
Small organic molecule
Emp. Form.:
C27H25N5O4S
Mol. Mass.:
515.583
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(cc3)C#N)cc(OC)cc2o1
Structure:
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