Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM35997
Substrate
n/a
Meas. Tech.
SPR biosensor assay Biacore T100
pH
7.4±n/a
Temperature
298.15±n/a K
Kd
38900±n/a nM
KOFF
49900 s-1
KON
1.94 M-1s-1
Citation
 Navratilova, I; Hopkins, AL Fragment Screening by Surface Plasmon Resonance ACS Med Chem Lett 1:44-8 (2010)   
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM35997
Synonyms:
1,4-dioxo-1,2,3,4-tetrahydro-1,2,3-benzothiadiazin-1-ium-1-olate | SPR_1
Type:
Small organic molecule
Emp. Form.:
C7H6N2O3S
Mol. Mass.:
198.199
SMILES:
O=C1NNS(=O)(=O)c2ccccc12
Structure:
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