Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM36331
Substrate
BDBM36388
Meas. Tech.
Assay name: Protease Inhibition Assay
pH
5.5±0
Temperature
310.15±0 K
IC50
1.2e+4±n/a nM
Citation
 Kato, D; Boatright, KM; Berger, AB; Nazif, T; Blum, G; Ryan, C; Chehade, KA; Salvesen, GS; Bogyo, M Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-8 (2005) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_RAT | Cathepsin H | Ctsh
Type:
PROTEIN
Mol. Mass.:
37114.31
Organism:
Rattus norvegicus
Description:
P00786
Residue:
333
Sequence:
MWTALPLLCAGAWLLSAGATAELTVNAIEKFHFTSWMKQHQKTYSSREYSHRLQVFANNWRKIQAHNQRNHTFKMGLNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMMTLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACASYPIPQV
  
Inhibitor
Name:
BDBM36331
Synonyms:
Ac-YFR-AMOK 10b
Type:
Small organic molecule
Emp. Form.:
C36H44N6O7
Mol. Mass.:
672.7706
SMILES:
[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c(-[#6])cccc1-[#6]
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM36388
Synonyms:
BDBM36404 | CID54445 | Octahydro-indolizine-1,6,7,8-tetraol, 13
Type:
Small organic molecule
Emp. Form.:
C8H15NO4
Mol. Mass.:
189.209
SMILES:
O[C@H]1CCN2C[C@H](O)[C@@H](O)[C@H](O)[C@@H]12
Structure:
Search PDB for entries with ligand similarity: