Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM36332
Substrate
Caspase-3 (7) Fluorogenic Substrate
Meas. Tech.
Enzyme kinetic assay
pH
7.4±0
Temperature
298.15±0 K
IC50
8.90e+5±n/a nM
Citation
 Lee, J; Bogyo, M Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem Biol 5:233-43 (2010) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
CASP3_MOUSE | Casp3 | Cpp32
Type:
PROTEIN
Mol. Mass.:
31476.45
Organism:
Mus musculus
Description:
EBI_101489
Residue:
277
Sequence:
MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM36332
Synonyms:
LI-1 | Legumain Inhibitor -1
Type:
Small organic molecule
Emp. Form.:
C15H22N4O7
Mol. Mass.:
370.3578
SMILES:
CCOC(=O)[C@H]1O[C@@H]1C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(C)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-3 (7) Fluorogenic Substrate
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
1477.75
Organism:
n/a
Description:
AFC = 7-Amino-4-trifluoromethylcoumarin
Residue:
16
Sequence:
ACASPGLVALASPAFC