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TargetReceptor-interacting protein 1 (RIPK1)
LigandBDBM36371
Substrate/Competitorn/a
Meas. Tech.RIP1 Kinase Assay
pH7.3±0
Temperature303.15±0 K
EC50 182±0.0 nM
Citation Degterev, AHitomi, JGermscheid, MCh'en, ILKorkina, OTeng, XAbbott, DCuny, GDYuan, CWagner, GHedrick, SMGerber, SALugovskoy, AYuan, J Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol4:313-21 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Receptor-interacting protein 1 (RIPK1)
Name:Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1
Synonyms:Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | RIP-1 | RIPK1 | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1
Type:Enzyme Catalytic Domain
Mol. Mass.:75926.99
Organism:Homo sapiens (Human)
Description:aa 8-327
Residue:671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36371
NameBDBM36371
Synonyms:5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, Nec-1 | CID2828334
TypeSmall organic molecule
Emp. Form.C13H13N3OS
Mol. Mass.259.327
SMILESCN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
Structure
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n/a