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TargetEstrogen receptor alpha D538G
LigandBDBM263665
Substrate/Competitorn/a
Meas. Tech.Estrogen Receptor Coactivator Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 30.0±n/a nM
Commentsextracted
Citation Bouaboula, MBrollo, MCertal, VEl-Ahmad, YFiloche-Romme, BHalley, FMcCort, GSchio, LTabart, MTerrier, CThompson, F Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof US Patent US9714221 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
Estrogen receptor alpha D538G
Name:Estrogen receptor alpha D538G
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:66173.42
Organism:Homo sapiens (Human)
Description:n/a
Residue:595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYGLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM263665
NameBDBM263665
Synonyms:5-[4-[(3S)- 1-(3- fluoro- propyl)pyrrolidin- 3-yl]oxyphenyl]- 6-(3-hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-3-ol5-[4-[(3S)- 1-(3- fluoro- propyl)pyrrolidin- 3-yl]oxyphenyl]- 6-(1H-indol-5-yl)- 8,9-dihydro- 7H- benzo[7]- annulen-3-ol6-(2- chloro-4- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-3-ol | US9714221, Example 2
TypeSmall organic molecule
Emp. Form.C30H32FNO3
Mol. Mass.473.5784
SMILESOc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2cc(O)ccc2CCC1 |r,c:8|
Structure
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n/a