Reaction Details Report a problem with these data
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM36497
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5±0
Temperature
298.15±0 K
Kd
1.9±0.0 nM
Citation
 Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | MTAN | MTNN_KLEP3 | Methylthioadenosine Nucleosidase (MTAN) | mtnN
Type:
Enzyme
Mol. Mass.:
24505.78
Organism:
Klebsiella pneumoniae
Description:
B5Y1L0
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTITIGGSEIYTGQLHGVDVALLKSGIGKVAAATGATLLLERCQPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLVAAAEDCIKALDLNAVRGLIVSGDAFINGSVALAKIRHNFPQAIAVEMEATAIAHVCHNFKVPFVVVRAISDVADQQSHLSFEEFLAVAARQSTLMVENLVQNLARG
  
Inhibitor
Name:
BDBM36497
Synonyms:
CHEMBL191436 | DADMe-ImmA-Bn
Type:
Small organic molecule
Emp. Form.:
C19H23N5OS
Mol. Mass.:
369.484
SMILES:
Nc1ncnc2c(CN3CC(O)C(CSCc4ccccc4)C3)c[nH]c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-Methylthioado | 5-methylthioadenosine | CHEMBL277041 | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.334
SMILES:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: