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TargetMethylthioadenosine Nucleosidase (MTAN)
LigandBDBM36498
Substrate/CompetitorBDBM22111
Meas. Tech.Enzyme Activity Assay
pH7.5±0
Temperature298.15±0 K
Kd 8±0.0 nM
Citation Gutierrez, JALuo, MSingh, VLi, LBrown, RLNorris, GEEvans, GBFurneaux, RHTyler, PCPainter, GFLenz, DHSchramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed]  Article
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Methylthioadenosine Nucleosidase (MTAN)
Name:Methylthioadenosine Nucleosidase (MTAN)
Synonyms:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | mtnN
Type:Enzyme
Mol. Mass.:24526.81
Organism:Staphylococcus aureus
Description:Q5HFG2
Residue:228
Sequence:
MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTL
LINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQS
SKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQT
CYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
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BDBM36498
NameBDBM36498
Synonyms:DADMe-ImmA-p-ClPh
TypeSmall organic molecule
Emp. Form.C18H20ClN5OS
Mol. Mass.389.902
SMILESNc1ncnc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12
Structure
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BDBM22111
NameBDBM22111
Synonyms:(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-Methylthioado | 5-methylthioadenosine | CHEMBL277041 | MTA
TypeNucleoside or nucleotide
Emp. Form.C11H15N5O3S
Mol. Mass.297.334
SMILESCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure
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