Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetFarnesyl diphosphate synthase
LigandBDBM36510
Substrate/CompetitorBDBM36499
Meas. Tech.Biophysical assay
pH7.4±0
Temperature296.15±0 K
IC50 2e+2± 0 nM
Citation Jahnke, WRondeau, JMCotesta, SMarzinzik, APellé, XGeiser, MStrauss, AGötte, MBitsch, FHemmig, RHenry, CLehmann, SGlickman, JFRoddy, TPStout, SJGreen, JR Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol6:660-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Farnesyl diphosphate synthase
Name:Farnesyl diphosphate synthase
Synonyms:Dimethylallyltranstransferase | FPP synthase | FPP synthetase | FPS | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36510
NameBDBM36510
Synonyms:1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid, 11 | CID46398840
TypeSmall organic molecule
Emp. Form.C15H11NO4
Mol. Mass.269.2521
SMILESOC(=O)Cn1c(cc2ccc3ccccc3c12)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM36499
NameBDBM36499
Synonyms:DMAPP | Dimethylallyl pyrophosphate
TypeSubstrate
Emp. Form.C5H9O6P2
Mol. Mass.227.0705
SMILES[#6]\[#6](-[#6])=[#6]\[#6]-[#8]P([#8-])(=O)P([#8-])([#8-])=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: