Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM8726
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
Ki
5e+3± 3.5e+4 nM
Citation
 Lu, H; England, K; am Ende, C; Truglio, JJ; Luckner, S; Reddy, BG; Marlenee, NL; Knudson, SE; Knudson, DL; Bowen, RA; Kisker, C; Slayden, RA; Tonge, PJ Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity. ACS Chem Biol 4:221-31 (2009) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADH] (ftuFabl) | fabl
Type:
Enzyme
Mol. Mass.:
27806.39
Organism:
Francisella tularensis
Description:
A0Q794
Residue:
260
Sequence:
MGFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVTSDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGIAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL
  
Inhibitor
Name:
BDBM8726
Synonyms:
5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35
Type:
Small organic molecule
Emp. Form.:
C12H7Cl3O2
Mol. Mass.:
289.542
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
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