Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM16298
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±0
Temperature
298.15±0 K
Ki
192±2 nM
Citation
 Lu, H; England, K; am Ende, C; Truglio, JJ; Luckner, S; Reddy, BG; Marlenee, NL; Knudson, SE; Knudson, DL; Bowen, RA; Kisker, C; Slayden, RA; Tonge, PJ Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity. ACS Chem Biol 4:221-31 (2009) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADH] (ftuFabl) | fabl
Type:
Enzyme
Mol. Mass.:
27806.39
Organism:
Francisella tularensis
Description:
A0Q794
Residue:
260
Sequence:
MGFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVTSDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGIAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL
  
Inhibitor
Name:
BDBM16298
Synonyms:
5-Octyl-2-phenoxy-phenol | 5-heptyl-2-phenoxylphenol | 5-octyl-2-phenoxyphenol | 8PP | AIDS227448 | CHEMBL505886 | PT05
Type:
Small organic molecule
Emp. Form.:
C20H26O2
Mol. Mass.:
298.4192
SMILES:
CCCCCCCCc1ccc(Oc2ccccc2)c(O)c1
Structure:
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