Reaction Details Report a problem with these data
Target
chymase
Ligand
BDBM88377
Substrate
n/a
Meas. Tech.
Enzymatic Chymase Assay
pH
7.5±n/a
IC50
3.50±n/a nM
Comments
extracted
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Zubov, D; Schamberger, J Substituted uracils as chymase inhibitors US Patent  US9695131 Publication Date 7/4/2017 
Target
Name:
chymase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
27507.42
Organism:
Mesocricetus auratus (Golden hamster)
Description:
A0A1U7QTH6
Residue:
247
Sequence:
MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNFVMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKANLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFEDFHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWINKILREN
  
Inhibitor
Name:
BDBM88377
Synonyms:
US9695131, 14
Type:
Small organic molecule
Emp. Form.:
C23H16F3N7O4
Mol. Mass.:
511.4128
SMILES:
Cn1c2ccc(cc2oc1=O)-n1cc(-c2nnn[nH]2)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O
Structure:
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