Reaction Details
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chymase
Ligand
BDBM88379
Substrate
n/a
Meas. Tech.
Enzymatic Chymase Assay
pH
7.5±n/a
IC50
2.80±n/a nM
Comments
extracted
Citation
Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Zubov, D; Schamberger, J Substituted uracils as chymase inhibitors US Patent US9695131 Publication Date 7/4/2017 More Info.:
Target
Name:
chymase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
27507.42
Organism:
Mesocricetus auratus (Golden hamster)
Description:
A0A1U7QTH6
Residue:
247
Sequence:
MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNFVMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKANLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFEDFHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWINKILREN
Inhibitor
Name:
BDBM88379
Synonyms:
US9695131, 16 | US9695131, 17 | US9695131, 18
Type:
Small organic molecule
Emp. Form.:
C23H19ClN8O3
Mol. Mass.:
490.902
SMILES:
Cn1c2ccc(cc2n(C)c1=O)-n1cc(-c2nnn[nH]2)c(=O)n(C2CCc3c2cccc3Cl)c1=O
Structure:
