Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM36637
Substrate
n/a
Meas. Tech.
Metallo-Beta-Lactamase Assay
pH
7±0
Temperature
310.15±0 K
IC50
4.2e+4± 1.0e+4 nM
Citation
 Toney, JH; Fitzgerald, PM; Grover-Sharma, N; Olson, SH; May, WJ; Sundelof, JG; Vanderwall, DE; Cleary, KA; Grant, SK; Wu, JK; Kozarich, JW; Pompliano, DL; Hammond, GG Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol 5:185-96 (1998) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Metallo-beta-lactamase
Type:
Protein
Mol. Mass.:
27160.75
Organism:
Bacteroides fragilis
Description:
Q8KZP2
Residue:
249
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTETLVNWVADSLHAKVTTFIPNHWHGDCIGGLGYLQKKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHPKQIVNQYIESTSKP
  
Inhibitor
Name:
BDBM36637
Synonyms:
L-809-558
Type:
Small organic molecule
Emp. Form.:
C20H15N7
Mol. Mass.:
353.38
SMILES:
C(c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)n1cnc2cccnc12
Structure:
Search PDB for entries with ligand similarity: