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TargetHIV-1 protease
LigandBDBM161
Substrate/Competitorn/a
Meas. Tech.Protease Inhibtion Assay
pH5.5±0
Ki 0.018±0.0 nM
Citation Rodgers, JDLam, PYJohnson, BLWang, HLi, RRu, YKo, SSSeitz, SPTrainor, GLAnderson, PSKlabe, RMBacheler, LTCordova, BGarber, SReid, CWright, MRChang, CHErickson-Viitanen, S Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol5:597-608 (1998) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 protease
Name:HIV-1 protease
Synonyms:HIV-1 protease wild type
Type:Protein
Mol. Mass.:10757.68
Organism:Human immunodeficiency virus
Description:O90785
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM161
NameBDBM161
Synonyms:(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(1H-indazol-5-ylmethyl)-1,3-diazepan-2-one | CHEMBL78671 | Cyclic Urea | Indazole, 1
Typen/a
Emp. Form.C35H34N6O3
Mol. Mass.586.6829
SMILESO[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3[nH]ncc3c2)C(=O)N(Cc2ccc3[nH]ncc3c2)[C@@H]1Cc1ccccc1
Structure
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n/a