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TargetHIV-1 protease
LigandBDBM36655
Substrate/Competitorn/a
Meas. Tech.Protease Inhibtion Assay
pH5.5±0
Ki 0.02±0.0 nM
Citation Rodgers, JDLam, PYJohnson, BLWang, HLi, RRu, YKo, SSSeitz, SPTrainor, GLAnderson, PSKlabe, RMBacheler, LTCordova, BGarber, SReid, CWright, MRChang, CHErickson-Viitanen, S Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol5:597-608 (1998) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 protease
Name:HIV-1 protease
Synonyms:HIV-1 protease wild type
Type:Protein
Mol. Mass.:10757.68
Organism:Human immunodeficiency virus
Description:O90785
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36655
NameBDBM36655
Synonyms:Cyclopropylmethyl cyclic urea
TypeSmall organic molecule
Emp. Form.C31H35N5O3
Mol. Mass.525.6413
SMILESNc1n[nH]c2ccc(CN3[C@H](Cc4ccccc4)[C@H](O)[C@@H](O)[C@@H](Cc4ccccc4)N(CC4CC4)C3=O)cc12 |r|
Structure
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