Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma [183-417]
Ligand
BDBM31889
Substrate
n/a
Meas. Tech.
Competitive Assay
pH
8±0
Temperature
277.15±0 K
Ki
1.5±0.0 nM
Citation
 Géhin, M; Vivat, V; Wurtz, JM; Losson, R; Chambon, P; Moras, D; Gronemeyer, H Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol 6:519-29 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma [183-417]
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic Acid Receptor, gamma
Type:
Ligand-binding domain
Mol. Mass.:
26502.27
Organism:
Homo sapiens (Human)
Description:
P13631[183-417]
Residue:
235
Sequence:
SPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLE
  
Inhibitor
Name:
BDBM31889
Synonyms:
BMS 961 | BMS270394 | BMS961
Type:
Small organic molecule
Emp. Form.:
C23H26FNO4
Mol. Mass.:
399.4552
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)C(=O)Nc1ccc(cc1F)C(O)=O
Structure:
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