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TargetTyrosine-protein kinase JAK2
LigandBDBM264132
Substrate/Competitorn/a
Meas. Tech.Jak2 Tyrosine Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 1300±n/a nM
Commentsextracted
Citation Ko, SSBatt, DGBertrand, MBDelucca, GLangevine, CMLiu, QSrivastava, ASWatterson, SH Carbazole carboxamide compounds US Patent US9714234 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK2
Name:Tyrosine-protein kinase JAK2
Synonyms:JAK-2 | JAK2 | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:Protein
Mol. Mass.:130684.68
Organism:Homo sapiens (Human)
Description:O60674
Residue:1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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  Blast E-value cutoff:
BDBM264132
NameBDBM264132
Synonyms:7-(2-Hydroxypropan-2-yl)-4-(3-(8-methoxy-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-9H-carbazole-1-carboxamide (Mixture of Four diastereomers) | US9714234, 7
TypeSmall organic molecule
Emp. Form.C33H30N4O5
Mol. Mass.562.6151
SMILESCOc1cccc2c1n(C)c(=O)n(-c1cccc(c1C)-c1ccc(C(N)=O)c3[nH]c4cc(ccc4c13)C(C)(C)O)c2=O |(8.25,-7.31,;6.91,-6.54,;6.91,-5,;8.25,-4.23,;8.25,-2.69,;6.91,-1.92,;5.58,-2.69,;5.58,-4.23,;4.25,-5,;4.25,-6.54,;2.91,-4.23,;1.58,-5,;2.91,-2.69,;1.58,-1.93,;.24,-2.69,;-1.09,-1.92,;-1.09,-.38,;.24,.38,;1.58,-.38,;1.98,1.1,;.24,1.93,;1.58,2.69,;1.58,4.23,;.24,5,;.24,6.54,;1.58,7.31,;-1.09,7.31,;-1.09,4.23,;-2.55,4.71,;-3.46,3.47,;-4.99,3.3,;-5.62,1.9,;-4.71,.65,;-3.18,.81,;-2.55,2.22,;-1.09,2.69,;-7.16,1.9,;-8.25,.81,;-6.76,.41,;-7.93,3.23,;4.25,-1.93,;4.25,-.38,)|
Structure
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