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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM264183
Substrate
n/a
Meas. Tech.
JAK Enzymatic Assay
pH
7.3±n/a
IC50
>30000±n/a nM
Comments
extracted
Citation
 Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent  US9714236 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM264183
Synonyms:
(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide | US10167276, Example 7a | US10654835, Example 7a | US11247983, Example 7a | US9714236, 7a
Type:
Small organic molecule
Emp. Form.:
C26H32FN9O2
Mol. Mass.:
521.5898
SMILES:
COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12 |r|
Structure:
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