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TargetJAK2 (831-1132)
LigandBDBM264188
Substrate/Competitorn/a
Meas. Tech.JAK Enzymatic Assay
pH7.3±n/a
IC50>30000±n/a nM
Commentsextracted
Citation Grimster, NKawatkar, SKettle, JGSu, QVasbinder, MChuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
JAK2 (831-1132)
Name:JAK2 (831-1132)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:35337.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:302
Sequence:
GFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE
HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH
IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV
KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQ
GQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM
AG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM264188
NameBDBM264188
Synonyms:(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide | US10167276, Example 10b | US9714236, 10b
TypeSmall organic molecule
Emp. Form.C27H34FN9O2
Mol. Mass.535.6164
SMILESCCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a