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TargetJAK1 (866-1154)
LigandBDBM264227
Substrate/Competitorn/a
Meas. Tech.JAK Enzymatic Assay
pH7.3±n/a
IC50 13.0±n/a nM
Commentsextracted
Citation Grimster, NKawatkar, SKettle, JGSu, QVasbinder, MChuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
JAK1 (866-1154)
Name:JAK1 (866-1154)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:34254.95
Organism:Homo sapiens (human)
Description:n/a
Residue:299
Sequence:
VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG
GNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKI
NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY
TVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPT
HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM264227
NameBDBM264227
Synonyms:(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide | US10167276, Example 47 | US9714236, 47
TypeSmall organic molecule
Emp. Form.C26H33N9O2
Mol. Mass.503.5993
SMILESCC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a