Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM264236
Substrate
n/a
Meas. Tech.
JAK Enzymatic Assay
pH
7.3±n/a
IC50
28.0±n/a nM
Comments
extracted
Citation
 Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent  US9714236 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM264236
Synonyms:
(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide | US10167276, Example 56 | US10654835, Example 56 | US11247983, Example 56 | US9714236, 56
Type:
Small organic molecule
Emp. Form.:
C25H30FN9O
Mol. Mass.:
491.5638
SMILES:
C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F |r|
Structure:
Search PDB for entries with ligand similarity: