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TargetJAK1 (866-1154)
LigandBDBM264239
Substrate/Competitorn/a
Meas. Tech.JAK Enzymatic Assay
pH7.3±n/a
IC50 69.0±n/a nM
Commentsextracted
Citation Grimster, NKawatkar, SKettle, JGSu, QVasbinder, MChuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017
More Info.:Get all data from this article,  Assay Method
 
JAK1 (866-1154)
Name:JAK1 (866-1154)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:34254.95
Organism:Homo sapiens (human)
Description:n/a
Residue:299
Sequence:
VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG
GNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKI
NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY
TVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPT
HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM264239
NameBDBM264239
Synonyms:(2R)-N-(3-{2-[(3- ethoxy-1-ethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 59 | US9714236, 59
TypeSmall organic molecule
Emp. Form.C28H37N9O2
Mol. Mass.531.6525
SMILESCCOc1nn(CC)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a